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Article

Identification and characterization of ATM founder mutation in BRCA-negative breast cancer patients of Arab ethnicity.

Scientific reports - 27 Nov 2023

Bu Rong, Siraj Abdul K, Al-Rasheed Maha, Iqbal Kaleem, Azam Saud, Qadri Zeeshan, Haqawi Wael, Tulbah Asma, Al-Dayel Fouad, Almalik Osama, Al-Kuraya Khawla S

Abstract excerpt

Breast cancer (BC) is the most prevalent malignancy among women worldwide with germline pathogenic variants/likely pathogenic variants (PVs/LPVs) in BRCA1/2 accounting for a large portion of hereditary cases. Recently, heterozygous PVs/LPVs in the ATM serine/threonine kinase or Ataxia-telangiectasia mutated gene (ATM) has been identified as a moderate susceptibility factor for BC in diverse ethnicities. However,...

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Identifiers

PMID: 38017116
DOI: 10.1038/s41598-023-48231-0
PMCID: PMC10684510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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