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Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan.

Neoplasia (New York, N.Y.) - 1 May 2024

Ahmad Hilal, Ali Asif, Ali Roshan, Khalil Ali Talha, Khan Ishaq, Khan Mah Muneer, Alorini Mohammed

Abstract excerpt

Gene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber...

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Identifiers

PMID: 38537553
DOI: 10.1016/j.neo.2024.100989
PMCID: PMC11026844

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