Article
Phenotype and pathological significance of MCAM+ (CD146+) T cell subset in psoriatic arthritis.
Molecular biology reports - 1 Oct 2021
Raychaudhuri Smriti K, Abria Christine, Raychaudhuri Siba P
Abstract excerpt
BACKGROUND: CD146 (MCAM-melanoma cell adhesion molecule) is a cell surface adhesion molecule for Laminin 411. T cells expressing MCAM are mainly responsible for IL-17 production. IL-17 secreting T helper cells (Th17 cells) are critical for the pathogenesis of psoriatic arthritis (PsA). Here we hypothesized enrichment of CD146+IL-17+ memory T cells in PsA synovium and studied the association of CD146 expression...
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