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Article

Hypermethylation of MCAM gene is associated with advanced tumor stage in prostate cancer

14 Jan 2008

Abstract excerpt

BACKGROUND: DNA methylation has emerged as a promising biomarker for prostate cancer detection. In this report, we screened 36 candidate genes generated by a bioinformatic analysis of the human genome, and found that the melanoma cell adhesion molecule (MCAM) was an excellent candidate for cancer-specific methylation in prostate cancer. METHODS: Direct sequencing of bisulfite-treated genomic DNA, conventional...

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Share to Epigenetics and DNA Methylation
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PMID: 18196513
DOI: 10.1002/pros.20709

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