Mutational profile and cardiovascular risk factors impact prognosis in triple-negative essential thrombocythemia.

doi:10.1038/s41375-026-03035-9

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Article

Mutational profile and cardiovascular risk factors impact prognosis in triple-negative essential thrombocythemia.

Leukemia - 1 Sept 2026

Carreño-Tarragona Gonzalo, Gil-Manso Rodrigo, Hernández-Boluda Juan Carlos, Martínez-Ávila José Carlos, Bellosillo Beatriz, Pérez-López Raúl, Segura Adrián, Ferrer-Marín Francisca, Arellano-Rodrigo Eduardo, Angona Anna, García-Gutiérrez Valentín, Noya María Soledad, Blanco Ángela, Zamora Lurdes, Navarro Miguel, Senín Alicia, Magro Elena, Pastor-Galán Irene, Mata-Vázquez María Isabel, Morales María Luz, Cuevas Beatriz, Vélez Patricia, Mora Elvira, Martínez-Bilbao Cristina, Colmenares Rafael, Alonso Juan Manuel, Pérez-Encinas Manuel, Caballero-Navarro Gonzalo, Cortés Miguel Ángel, Santaliestra Marta, Raya José María, Blanco-Sánchez Alberto, Hernández-Rivas Jesús María, Martínez-López Joaquín, Ayala Rosa, Álvarez-Larrán Alberto

Abstract excerpt

Triple-negative essential thrombocythemia (TN-ET) represents a diagnostic and therapeutic challenge. The aim of the present study was to identify prognostic factors useful for tailoring treatment. 241 TN-ET patients with myeloid panel sequencing and confirmatory bone marrow biopsy were selected. Pathogenic/likely pathogenic variants were identified in 19.5% of patients. Mutation carriers were older (median age 66...

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