Article

Understanding the development of enzalutamide resistance based on a functional single-cell approach

2024-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Most metastatic prostate cancers (PCa) initially depend on androgen for survival and proliferation. Thus, anti-androgen or castration therapies are the mainstay treatment. Although effective at first, androgen-dependent PCa (ADPC) universally develops therapy resistance, thereby evolving to the incurable disease, called castration resistant PCa (CRPC). Currently, mechanisms underlying the emerge...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6f6f628-e3d8-5862-8511-916b983d7f26
DOI: 10.1101/2024.10.20.619319

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Understanding the development of enzalutamide resistance based on a functional single-cell approachDOI 10.1101/2024.10.20.619319Read

Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responsesSemantic proximity Read

Identification of genes required for enzalutamide resistance in castration-resistant prostate cancer cells <i>in vitro</i>Semantic proximity Read

Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle–Related Transcription and Attenuated Androgen ResponseSemantic proximity Read

Androgen receptor (AR) heterogeneity in prostate cancer and therapy resistanceSemantic proximity Read

Enzalutamide-induced signatures revealed by epigenetic plasticity using single-cell multi-omics sequencing in prostate cancerSemantic proximity Read

Single-cell analysis supports key cell subpopulations for drug resistance and metastasis in prostate cancerSemantic proximity Read

Integrating pharmacogenomics data-driven prediction with bulk and single-cell RNAseq to demonstrate the efficacy of an NAMPT inhibitor against aggressive, taxane-resistant, and stem-like cells in lethal prostate cancerSemantic proximity Read

Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancerSemantic proximity Read

Phenotypic and transcriptomic characterization of bicalutamide and enzalutamide resistance in castration-resistant prostate cancer cellsSemantic proximity Read

Notch as a Driver of Lineage Plasticity and Therapeutic Target in Enzalutamide-Resistant Prostate CancerSemantic proximity Read

Next-generation Sequencing of Advanced Prostate Cancer Treated with Androgen-deprivation TherapySemantic proximity Read

GG-NER's role in androgen receptor signaling inhibitor response for advanced prostate cancer.Semantic proximity Read