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AAV8-antiVEGFfab Ocular Gene Transfer for Neovascular Age-Related Macular Degeneration

8 Dec 2017

Abstract excerpt

Sustained suppression of VEGF is needed in many patients with neovascular age-related macular degeneration (NVAMD), and gene transfer of a VEGF-neutralizing protein is a promising approach to achieve it. Initial clinical trials testing this approach have shown encouraging signals, but evidence of robust transgene expression and consistent antiangiogenic and antipermeability activity has been lacking. In this...

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PMID: 29292162
DOI: 10.1016/j.ymthe.2017.12.002

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