Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Helper-Dependent Adenovirus Transduces the Human and Rat Retina but Elicits an Inflammatory Reaction When Delivered Subretinally in Rats

28 Aug 2019

Abstract excerpt

The identification of >100 genes causing inherited retinal degeneration and the promising results of recent gene augmentation trials have led to an increase in the number of studies investigating the preclinical efficacy of viral-mediated gene transfer. Despite success using adeno-associated viruses, many disease-causing genes, such as ABCA4 or USH2A, are too large to fit into these vectors. One option for large...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mosquito-borne diseases and control
Share to Retinal Development and Disorders
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31456426
DOI: 10.1089/hum.2019.159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Helper-Dependent Adenovirus Transduces the Human and Rat Retina but Elicits an Inflammatory Reaction When Delivered Subretinally in RatsPMID 31456426Read ↗

Helper‐dependent adenovirus for the gene therapy of proliferative retinopathies: stable gene transfer, regulated gene expression and therapeutic efficacySemantic proximity Read ↗

AAV-delivered CRISPR-Cas9 elicits persistent retinal immune responses compared with transient responses to RNPSemantic proximity Read ↗

Adeno-associated virus vectors for retinal gene therapy in basic research and clinical studiesSemantic proximity Read ↗

Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primatesSemantic proximity Read ↗

Adeno-associated viral vectors for retinal gene transfer and treatment of retinal diseases.Semantic proximity Read ↗

Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future PerspectivesSemantic proximity Read ↗

Helper-dependent adenoviral vectors in experimental gene therapy.Semantic proximity Read ↗

Cellular Immune Responses Induced by Subretinal AAV Gene Transfer can be Restrained by the Subretinal Associated Immune Inhibition MechanismSemantic proximity Read ↗

The induction of inflammation by adenovirus vectors used for gene therapySemantic proximity Read ↗

Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retinaSemantic proximity Read ↗

Risk Mitigation of Immunogenicity: A Key to Personalized Retinal Gene TherapySemantic proximity Read ↗

Conventional and Tropism-Modified High-Capacity Adenoviral Vectors Exhibit Similar Transduction Profiles in Human iPSC-Derived Retinal OrganoidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.