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Article

Small-Molecule Antagonists of p53-MDM2 Binding: Research Tools and Potential Therapeutics

2 Apr 2004

Abstract excerpt

p53 regulates a key pathway which protects normal tissues from tumor development that may result from diverse forms of stress. In the absence of stress, growth suppressive and proapoptotic activity of p53 is inhibited by MDM2 which binds p53 and negatively regulates its activity and stability. MDM2 antagonists could activate p53 and may offer a novel therapeutic approach to cancer. Recently, we identified the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 15004525
DOI: 10.4161/cc.3.4.801

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