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Article

Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Oct 2023

Pettit Rowland W, Byun Jinyoung, Han Younghun, Ostrom Quinn T, Coarfa Cristian, Bondy Melissa L, Amos Christopher I

Abstract excerpt

INTRODUCTION: Lung cancer is a complex polygenic disorder. Analysis with Mendelian randomization (MR) allows for genetically predicted risks to be estimated between exposures and outcomes. METHODS: We analyzed 345 heritable traits from the United Kingdom Biobank and estimated their associated effects on lung cancer outcomes using two sample MR. In addition to estimating effects with overall lung cancer,...

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Carcinoma, Non-Small-Cell Lung
IMPACT gene
Genome-Wide Association Study
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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PMID: 37530747
DOI: 10.1158/1055-9965.EPI-22-0698
PMCID: PMC10651112

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IMPACT

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