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Article

Impact of SARS-CoV-2 Infection (COVID-19) on Cytochromes P450 Activity Assessed by the Geneva Cocktail.

Clinical pharmacology and therapeutics - 1 Nov 2021

Lenoir Camille, Terrier Jean, Gloor Yvonne, Curtin François, Rollason Victoria, Desmeules Jules Alexandre, Daali Youssef, Reny Jean-Luc, Samer Caroline Flora

Abstract excerpt

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is a severe acute respiratory syndrome with an underlying inflammatory state. We have previously demonstrated that acute inflammation modulates cytochromes P450 (CYPs) activity in an isoform-specific manner. We therefore hypothesized that COVID-19 might also impact CYP activity, and thus aimed to...

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Source

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Identifiers

PMID: 34473836
DOI: 10.1002/cpt.2412
PMCID: PMC8653122

Genes

CRP
CYP1A2
TNF
CYP2B6
CYP2C19
CYP2C9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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