Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.

Blood - 2 Oct 2014

Gough Daniel J, Marié Isabelle J, Lobry Camille, Aifantis Iannis, Levy David E

Abstract excerpt

Juvenile myelomonocytic leukemia, acute myeloid leukemia (AML), and other myeloproliferative neoplasms (MPNs) are genetically heterogeneous but frequently display activating mutations in Ras GTPases and activation of signal transducer and activator of transcription 3 (STAT3). Altered STAT3 activity is observed in up to 50% of AML correlating with poor prognosis. Activated STAT proteins, classically associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cells
Share to Myeloid Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Myeloproliferative Disorders

Share to ras GTPase-Activating Proteins

Share to Serine

Share to STAT3 Transcription Factor

Share to Stem Cells

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 25150294
DOI: 10.1182/blood-2013-02-484196
PMCID: PMC4183984

Genes

STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.PMID 25150294Read ↗

STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.Semantic proximity Read ↗

Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer.Semantic proximity Read ↗

Somatic activation of oncogenic <i>Kras</i> in hematopoietic cells initiates a rapidly fatal myeloproliferative disorderSemantic proximity Read ↗

Wild-type Kras expands and exhausts hematopoietic stem cells.Semantic proximity Read ↗

Targeting RAS Signaling Pathways in Juvenile Myelomonocytic LeukemiaSemantic proximity Read ↗

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.Semantic proximity Read ↗

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.Semantic proximity Read ↗

Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPNSemantic proximity Read ↗

A patient-based murine model recapitulates human STAT3 gain-of-function syndrome.Semantic proximity Read ↗

Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation.Semantic proximity Read ↗

Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype.Semantic proximity Read ↗

Requirement for p85alpha regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.