Article

More efficacious drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1

2015-08-07

Abstract excerpt

In the early days of HIV treatment, drug resistance occurred rapidly and predictably in all patients, but under modern treatments, resistance arises slowly, if at all. The probability of resistance should be controlled by the rate of generation of resistant mutations. If many adaptive mutations arise simultaneously, then adaptation proceeds by soft selective sweeps in which multiple adaptive mutations spread conco...

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Literature Corpus work: a6812c11-89d5-5237-8c6f-d5ab5240c1b3
DOI: 10.1101/024109

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