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Article

Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans.

Cell death & disease - 11 Jan 2024

Zimmer J, Mueller L, Frank-Herrmann P, Rehnitz J, Dietrich J E, Bettendorf M, Strowitzki T, Krivega M

Abstract excerpt

Development of the gonads under complex androgen regulation is critical for germ cells specification. In this work we addressed the relationship between androgens and genomic integrity determining human fertility. We used different study groups: individuals with Differences of Sex Development (DSD), including Complete Androgen Insensitivity Syndrome (CAIS) due to mutated androgen receptor (AR), and men with...

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Source

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Identifiers

PMID: 38212646
DOI: 10.1038/s41419-023-06397-5
PMCID: PMC10784536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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