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Deciphering the regulatory networks of human male germline development from embryo to adulthood

21 May 2025

Abstract excerpt

Male germline development is crucial for the proper establishment of spermatogonial stem cell pool and life-long production of spermatozoa, but the full-term developmental profiling of human male germline is not fully understood. Here, by integrating 92,488 human testicular cells spanning from six-week-old embryos to old men, we constructed a comprehensive human male germ cell atlas. Further analysis found that...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40409516
DOI: 10.1016/j.bbadis.2025.167918

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