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Article

SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern.

Journal of chemical information and modeling - 27 Sept 2021

Triveri Alice, Serapian Stefano A, Marchetti Filippo, Doria Filippo, Pavoni Silvia, Cinquini Fabrizio, Moroni Elisabetta, Rasola Andrea, Frigerio Francesco, Colombo Giorgio

Abstract excerpt

The SARS-CoV-2 spike (S) protein is exposed on the viral surface and is the first point of contact between the virus and the host. For these reasons it represents the prime target for Covid-19 vaccines. In recent months, variants of this protein have started to emerge. Their ability to reduce or evade recognition by S-targeting antibodies poses a threat to immunological treatments and raises concerns for their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34468141
DOI: 10.1021/acs.jcim.1c00857
PMCID: PMC8479857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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