Article

Rational Design of SARS-CoV-2 Spike Glycoproteins To Increase Immunogenicity By T Cell Epitope Engineering

2020-08-14

Abstract excerpt

The current COVID-19 pandemic caused by SARS-CoV-2 has resulted in millions of confirmed cases and thousands of deaths globally. Extensive efforts and progress have been made to develop effective and safe vaccines against COVID-19. A primary target of these vaccines is the SARS-CoV-2 spike (S) protein, and many studies utilized structural vaccinology techniques to either stabilize the protein or fix the receptor-b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e615e0b2-7cf6-5f9a-9ac4-24062b93d195
DOI: 10.1101/2020.08.14.251496

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rational Design of SARS-CoV-2 Spike Glycoproteins To Increase Immunogenicity By T Cell Epitope EngineeringDOI 10.1101/2020.08.14.251496Read

Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineeringSemantic proximity Read

Computationally designed multi-epitope vaccine construct targeting the SARS-CoV-2 spike protein elicits robust immune responses in silicoSemantic proximity Read

Designing a novel vaccine against COVID-19 based on spike SARS-Cov-2 notable mutations using immunoinformatics approaches.Semantic proximity Read

Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicitySemantic proximity Read

The multi-epitope vaccine prediction to combat Pandemic SARS-CoV-2, an immunoinformatic approachSemantic proximity Read

A pan-human coronavirus recombinant vaccine designed from conserved structural epitopes to counter emerging SARS-CoV-2 variantsSemantic proximity Read

Identification of promising SARS-CoV-2 CD8+ and CD4+ T cell epitopes by immunoinformatics approach for a multi-epitope-based vaccine designSemantic proximity Read

Protein design for evaluating vaccines against future viral variationSemantic proximity Read

Multiepitope Subunit Vaccine Design against COVID‐19 Based on the Spike Protein of SARS‐CoV‐2: An In Silico AnalysisSemantic proximity Read

Genome based Evolutionary study of SARS-CoV-2 towards the Prediction of Epitope Based Chimeric VaccineSemantic proximity Read

Design of T cell epitope-based vaccine candidate for SARS-CoV-2 targeting nucleocapsid and spike protein escape variantsSemantic proximity Read

Immunoinformatics design of a structural proteins driven multi-epitope candidate vaccine against different SARS-CoV-2 variants based on fynomerSemantic proximity Read