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Article

ABCB1 C3435T, G2677T/A and C1236T variants have no effect in eslicarbazepine pharmacokinetics.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Oct 2021

Zubiaur Pablo, Del Peso-Casado Miriam, Ochoa Dolores, Enrique-Benedito Teresa, Mejía-Abril Gina, Navares Marcos, Villapalos-García Gonzalo, Román Manuel, Abad-Santos Francisco, Ovejero-Benito María Carmen

Abstract excerpt

Eslicarbazepine acetate is a third-generation anti-epileptic prodrug quickly and extensively transformed to eslicarbazepine after oral administration. Reduction in seizure frequency in patients managed with eslicarbazepine is only partial in the majority of patients and many of them suffer considerable ADRs that require a change of treatment. The P-glycoprotein, encoded by the ABCB1 gene, is expressed throughout...

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Identifiers

PMID: 34463270
DOI: 10.1016/j.biopha.2021.112083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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