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Article

ATP-binding cassette transporter polymorphisms and the pharmacokinetics of oral esketamine.

Pharmacogenomics - 1 Jan 2025

Oude Nijhuis Jérôme C, Coerts Daniël T, van Dalfsen Jens H, Smith-Apeldoorn Sanne Y, Veraart Jolien K E, Schoevers Robert A, Touw Daan J, van Schaik Ron H N, Tamminga Wim J

Abstract excerpt

Oral esketamine is a promising new therapy for treatment-resistant depression. However, concerns exist about interindividual pharmacokinetic variability. Genetic polymorphisms regulating the expression of ATP-binding cassette (ABC) transporters might influence bioavailability. Utilizing blood samples from a placebo-controlled trial investigating repeated, low dose oral esketamine (N = 18), we performed ABCB1...

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Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41560413
DOI: 10.1080/14622416.2026.2617376
PMCID: PMC12915789

Genes

ABCB1
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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