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Cell Cycle-Coupled Changes in the Level of Reactive Oxygen Species Support the Proliferation of Human Pluripotent Stem Cells

21 Sept 2021

Abstract excerpt

Abstract The study of proliferation regulation in human pluripotent stem cells is crucial to gain insights into understanding the physiology of these cells. However, redox regulation of the pluripotent cell cycle remains largely unexplored. Here, using human embryonic stem cells (hESCs) as well as human induced pluripotent stem cells (hiPSCs), we demonstrate that the level of reactive oxygen species (ROS) in...

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PMID: 34460135
DOI: 10.1002/stem.3450

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