Article
Lengthened G1 phase indicates differentiation status in human embryonic stem cells.
Stem cells and development - 15 Jan 2013
Calder Ashley, Roth-Albin Ivana, Bhatia Sonam, Pilquil Carlos, Lee Jong Hee, Bhatia Mick, Levadoux-Martin Marilyne, McNicol Jamie, Russell Jennifer, Collins Tony, Draper Jonathan S
Abstract excerpt
The cell cycle in pluripotent stem cells is notable for the brevity of the G1 phase, permitting rapid proliferation and reducing the duration of differentiation signal sensitivity associated with the G1 phase. Changes in the length of G1 phase are understood to accompany the differentiation of human embryonic stem cells (hESCs), but the timing and extent of such changes are poorly defined. Understanding the early...
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