Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development

28 Jul 2021

Abstract excerpt

Epithelial ovarian cancer (EOC) is the most lethal disease of the female reproductive tract, and although most patients respond to the initial treatment with platinum (cPt)-based compounds, relapse is very common. We investigated the role of epigenetic changes in cPt-sensitive and -resistant EOC cell lines and found distinct differences in their enhancer landscape. Clinical data revealed that two genes (JAK1 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Remodeling and Cancer
Share to Ovarian cancer diagnosis and treatment
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34359703
DOI: 10.3390/cancers13153801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance DevelopmentPMID 34359703Read ↗

A Comparative Analysis of Genetic and Epigenetic Events of Breast and Ovarian Cancer Related to Tumorigenesis.Semantic proximity Read ↗

Decoding gene regulatory circuitry underlying TNBC chemoresistance reveals biomarkers for therapy response and therapeutic targetsSemantic proximity Read ↗

Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer.Semantic proximity Read ↗

Identification of Key Genes, miRNAs and miRNAs-mRNA Regulatory Pathways for Chemotherapy Resistance in Ovarian CancerSemantic proximity Read ↗

Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell TumorsSemantic proximity Read ↗

Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insightsSemantic proximity Read ↗

RRM2 as a Key Biomarker and Therapeutic Target in Letrozole-Resistant ER+ Breast Cancer: Insights from Bioinformatics and Molecular DockingSemantic proximity Read ↗

Deciphering the role of miR-506 in ovarian cancer drug sensitivitySemantic proximity Read ↗

Widespread reorganisation of the regulatory chromatin landscape facilitates resistance to inhibition of oncogenic ERBB2 signallingSemantic proximity Read ↗

A novel role for the tumor suppressor gene <i>ITF2</i> in lung tumorigenesis and chemotherapy responseSemantic proximity Read ↗

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy ResistanceSemantic proximity Read ↗

G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.