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Article

Effect of Lysyl Oxidase G473 A Polymorphism on Lysyl Oxidase and Total Soluble Collagen Expression in Oral Submucous Fibrosis.

Asian Pacific journal of cancer prevention : APJCP - 1 Aug 2021

Mukherjee Sanjit, Katarkar Atul, Dhariwal Richa, Mohanty Sweta, Mahato Basudev, Ray Jay Gopal, Chaudhuri Keya

Abstract excerpt

BACKGROUND: Oral submucous fibrosis (OSF) is a debilitating collagen-metabolic disorder leading to submucosal fibrosis and trismus. Lysyl oxidase (LOX), a critical collagen biosynthetic enzyme, is up-regulated in OSF. Polymorphisms in the Lysyl oxidase gene have been associated with increased risk of OSF and might affect normal collagen synthesis, accumulation, or degradation, crucial in determining fibrosis...

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Identifiers

PMID: 34452563
DOI: 10.31557/APJCP.2021.22.8.2493
PMCID: PMC8629460

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