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Article

Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jan 2009

Shieh Tzong-Ming, Tu His-Feng, Ku Ti-Hsuan, Chang Shu-Shin, Chang Kuo-Wei, Liu Chung-Ji

Abstract excerpt

OBJECTIVE: Areca use is the major cause for oral squamous cell carcinoma and oral submucous fibrosis (OSF) in South Asians. Lysyl oxidase (LOX) is a copper-activated enzyme critical for collagen cross-linking and organization of extracellular matrix. The presence of a G to A polymorphism at nucleotide 473 caused a non-conservative Arg158Gln change in the LOX amino acid sequence. OSF is a precancerous lesions...

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Source

Identifiers

PMID: 18764858
DOI: 10.1111/j.1600-0714.2008.00695.x

Genes

LOX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers.PMID 18764858Read ↗

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Effect of Lysyl Oxidase G473 A Polymorphism on Lysyl Oxidase and Total Soluble Collagen Expression in Oral Submucous Fibrosis.Semantic proximity Read ↗

Association of NQO1 C609T (Pro187Ser) with risk of Oral Submucous Fibrosis in Eastern Indian populationSemantic proximity Read ↗

The functional (-1171 5A-->6A) polymorphisms of matrix metalloproteinase 3 gene as a risk factor for oral submucous fibrosis among male areca users.Semantic proximity Read ↗

Transforming growth factor-β-1 polymorphisms are infrequent but exist at selected loci in oral submucous fibrosis.Semantic proximity Read ↗

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