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Article

A systematic review and network meta-analysis of single nucleotide polymorphisms associated with oral submucous fibrosis risk.

Medicine - 4 Sept 2026

Huang Chunxia, Liu Juan, Zeng Bin, Zhang Lele, Zhou Zhihang, Huang Xiaoshan, He Binsheng, Bao Meihua

Abstract excerpt

BACKGROUND: Oral submucous fibrosis (OSF) is a chronic and insidious oral disease characterized by hyalinization of the subepithelial connective tissue and progressive fibrosis of the oral submucosa. It is a precancerous condition of oral squamous cell carcinoma. Studies have demonstrated that single nucleotide polymorphisms (SNPs) are closely associated with susceptibility to OSF. This study aims to...

Read the complete abstract on PubMed

Topics

Humans
Oral Submucous Fibrosis
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease
Cytochrome P-450 CYP1A1
Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Factors

Bayes Theorem

Matrix Metalloproteinase 2

Source

Open in PubMed Open full text

Identifiers

PMID: 42700036
DOI: 10.1097/MD.0000000000050594
PMCID: PMC13549584

Genes

CYP1A1
MMP3
XRCC3
GSTM1
GSTT1
MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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