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Article

DOC-2/DAB2 interactive protein destabilizes c-Myc to impair the growth and self-renewal of colon tumor-repopulating cells.

Cancer science - 1 Nov 2021

Li Haiou, Zhou Yunjiao, Wang Meng, Wang Haizhou, Zhang Yangyang, Peng Ruyi, Zhang Ruike, Zhang Meng, Zhang Mengna, Qiu Peishan, Liu Lan, Zhao Qiu, Liu Jing

Abstract excerpt

Colorectal carcinoma (CRC) remains a huge challenge in clinical treatment due to tumor metastasis and recurrence. Stem cell-like colon tumor-repopulating cells (TRCs) are a subpopulation of cancer cells with highly tumorigenic and chemotherapy resistant properties. The core transcription factor c-Myc is essential for maintaining cancer stem-like cell phenotypes, yet its roles and regulatory mechanisms remain...

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Source

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Identifiers

PMID: 34449943
DOI: 10.1111/cas.15120
PMCID: PMC8586666

Genes

DAB2IP
DAB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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