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Article

circCTIC1 promotes the self-renewal of colon TICs through BPTF-dependent c-Myc expression

1 Nov 2018

Abstract excerpt

Colon tumor is a conman tumor in the world. There are various kinds of cells in colon tumor bulk, and only a small population can initiate tumor efficiently and termed as tumor-initiating cells (TICs). With self-renewal and differentiation capacities, colon TICs drive colon tumorigenesis, metastasis and relapse. However, the molecular mechanisms of colon TICs self-renewal are elusive. Here, we found that circular...

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PMID: 30403769
DOI: 10.1093/carcin/bgy144

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