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Article

RNA editing restricts hyperactive ciliary kinases.

Science (New York, N.Y.) - 27 Aug 2021

Li Dongdong, Liu Yufan, Yi Peishan, Zhu Zhiwen, Li Wei, Zhang Qiangfeng Cliff, Li Jin Billy, Ou Guangshuo

Abstract excerpt

Protein kinase activity must be precisely regulated, but how a cell governs hyperactive kinases remains unclear. In this study, we generated a constitutively active mitogen-activated protein kinase DYF-5 (DYF-5CA) in Caenorhabditis elegans that disrupted sensory cilia. Genetic suppressor screens identified that mutations of ADR-2, an RNA adenosine deaminase, rescued ciliary phenotypes of dyf-5CA We found that...

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Identifiers

PMID: 34446600
DOI: 10.1126/science.abd8971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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