Article
Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22.
Blood - 23 Apr 2009
Hughes Tiffany, Becknell Brian, McClory Susan, Briercheck Edward, Freud Aharon G, Zhang Xiaoli, Mao Hsiaoyin, Nuovo Gerard, Yu Jianhua, Caligiuri Michael A
Abstract excerpt
Considerable functional heterogeneity within human natural killer (NK) cells has been revealed through the characterization of distinct NK-cell subsets. Accordingly, a small subset of CD56(+)NKp44(+)NK cells, termed NK-22 cells, was recently described within secondary lymphoid tissue (SLT) as IL-22(-) when resting, with a minor fraction of this population becoming IL-22(+) when activated. Here we discover that...
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