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Article

Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology.

Genes - 31 Jul 2021

Burt Olivia, Johnston Keira J A, Graham Nicholas, Cullen Breda, Lyall Donald M, Lyall Laura M, Pell Jill P, Ward Joey, Smith Daniel J, Strawbridge Rona J

Abstract excerpt

BACKGROUND: The link between cardiometabolic and psychiatric illness has long been attributed to human behaviour, however recent research highlights shared biological mechanisms. The ASTN2 locus has been previously implicated in psychiatric and cardiometabolic traits, therefore this study aimed to systematically investigate the genetic architecture of ASTN2 in relation to a wide range of relevant traits. METHODS:...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34440368
DOI: 10.3390/genes12081194
PMCID: PMC8391428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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