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Article

Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition

25 Aug 2021

Abstract excerpt

Objectives Epigenomic alterations in cancer interact with the immune microenvironment to dictate tumour evolution and therapeutic response. We aimed to study the regulation of the tumour immune microenvironment through epigenetic alternate promoter use in gastric cancer and to expand our findings to other gastrointestinal tumours. Design Alternate promoter burden (APB) was quantified using a novel bioinformatic...

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PMID: 34433583
DOI: 10.1136/gutjnl-2021-324420

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