Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T-bet+CD8+ T cells govern anti-PD-1 responses in microsatellite-stable gastric cancers

25 Apr 2025

Abstract excerpt

More than 90% of advanced gastric cancers (GC) are microsatellite-stable (MSS). Compared to the high response rate of immune checkpoint inhibitors (ICI) in microsatellite-instability-high (MSI-H) GCs, only 10% of unstratified MSS GCs respond to ICIs. In this study, we apply semi-supervised learning to stratify potential ICI responders in MSS GCs, achieving high accuracy, quantified by an area under the curve of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Gastrointestinal Tumor Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40280928
DOI: 10.1038/s41467-025-58958-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T-bet+CD8+ T cells govern anti-PD-1 responses in microsatellite-stable gastric cancersPMID 40280928Read ↗

Single-cell and spatial transcriptomic profiling reveals impaired tertiary lymphoid structure maturation associated with T cell exhaustion in gastric cancerSemantic proximity Read ↗

Gastric Cancer Tumor Immune Microenvironment Landscape: Clinical Implications for Patient Outcome and Response to PD-1 Immune Checkpoint BlockadeSemantic proximity Read ↗

Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancerSemantic proximity Read ↗

Immune Microenvironment Spatial Landscapes of Tertiary Lymphoid Structures in Gastric CancerSemantic proximity Read ↗

Dynamic single-cell mapping unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment responseSemantic proximity Read ↗

Single-cell profiling of gastric cancer ascites reveals immunosuppressive remodeling and an epithelial-immune dual phenotype signature predictive for PD-1 immunotherapy responsesSemantic proximity Read ↗

Deciphering of intra‐tumoural heterogeneity and the interplay between metastasis‐associated meta‐program and myofibroblasts in gastric cancerSemantic proximity Read ↗

Integrative Multi-Omics Analysis Uncovers Immunological Phenotypes Predictive of Combinatorial Immunotherapy Response in Gastric Cancer.Semantic proximity Read ↗

Single-cell RNA sequencing revealed the T cell heterogeneity and exhaustion subsets of Helicobacter pylori-induced gastritis - cancer transformationSemantic proximity Read ↗

Longer survival of Helicobacter pylori positive gastric cancer patients is associated with a more active T cell immune response as revealed by single-cell sequencingSemantic proximity Read ↗

TM-Score predicts immunotherapy efficacy and improves the performance of the machine learning prognostic model in gastric cancer.Semantic proximity Read ↗

Comprehensive immunophenotyping of gastric adenocarcinoma identifies an inflamed class of tumors amenable to immunotherapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.