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Article

Restoration of keratinocytic phenotypes in autonomous trisomy-rescued cells.

Stem cell research & therapy - 25 Aug 2021

Tanuma-Takahashi Akiko, Inoue Momoko, Kajiwara Kazuhiro, Takagi Ryo, Yamaguchi Ayumi, Samura Osamu, Akutsu Hidenori, Sago Haruhiko, Kiyono Tohru, Okamoto Aikou, Umezawa Akihiro

Abstract excerpt

BACKGROUND: An extra copy of chromosome 21 in humans can alter cellular phenotypes as well as immune and metabolic systems. Down syndrome is associated with many health-related problems and age-related disorders including dermatological abnormalities. However, few studies have focused on the impact of trisomy 21 (T21) on epidermal stem cells and progenitor cell dysfunction. Here, we investigated the differences...

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Identifiers

PMID: 34433490
DOI: 10.1186/s13287-021-02448-w
PMCID: PMC8390253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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