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Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome

18 Apr 2012

Abstract excerpt

INTRODUCTION: Down syndrome (DS), a major cause of mental retardation, is caused by trisomy of some or all of human chromosome 21 and includes three basic karyotypes: trisomy 21, translocation, and mosaicism. The derivation of DS-specific induced pluripotent stem cells (iPSCs) provides us novel DS models that can be used to determine the DS mechanism and to devise therapeutic approaches for DS patients. METHODS:...

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PMID: 22512921
DOI: 10.1186/scrt105

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