Article
Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism.
Journal of genetics and genomics = Yi chuan xue bao - 1 Feb 2022
Wang Lu, Li Jinchen, Wang Chan, Tang Ruqi, Liang Jialong, Gong Yuhua, Dai Yaping, Ding Ningling, Wu Jian, Dai Na, Liu Lei, Zhao Yi, Shao Youlin, Zhao Weifeng, Jiang Peng, Shi Xingjuan, Chen Weichang, Tian Ye, Liu Xiangdong, Ma Xiong, Sun Zhongsheng
Abstract excerpt
Primary biliary cholangitis (PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental...
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