Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of KIAA1549-BRAF fusion gene expression and IDH1/IDH2 mutations in low grade pediatric astrocytomas.

Journal of neuro-oncology - 1 Apr 2014

Cruz Gabriela Rampazzo, Dias Oliveira Indhira, Moraes Laís, Del Giudice Paniago Mário, de Seixas Alves Maria Teresa, Capellano Andrea Maria, Saba-Silva Nasjla, Cavalheiro Sérgio, Cerutti Janete Maria, Toledo Silvia Regina Caminada

Abstract excerpt

Low-grade astrocytomas comprise about 30 % of the central nervous system tumors in children. Several investigations have searched a correlation between the BRAF gene fusions alterations and mutations at IDH1 and IDH2 genes in low grade pediatric astrocytomas. This study identified the expression of KIAA1549-BRAF fusion gene and BRAF V600E mutation, mutations at exon 4 of the IDH1 and IDH2 genes in samples of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma
Share to Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant, Newborn

Share to Isocitrate Dehydrogenase

Share to Neoplasm Grading

Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Proteins B-raf

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 24532263
DOI: 10.1007/s11060-014-1398-1

Genes

BRAF
IDH1
IDH2

Variants

rs11554137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of KIAA1549-BRAF fusion gene expression and IDH1/IDH2 mutations in low grade pediatric astrocytomas.PMID 24532263Read ↗

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.Semantic proximity Read ↗

Analysis of IDH1-R132 mutation, BRAF V600 mutation and KIAA1549-BRAF fusion transcript status in central nervous system tumors supports pediatric tumor classification.Semantic proximity Read ↗

Concomitant KIAA1549-BRAF fusion and IDH mutation in Pediatric spinal cord astrocytoma: a case report and literature review.Semantic proximity Read ↗

The Transcriptomic Landscape of Pediatric Astrocytoma.Semantic proximity Read ↗

IDH1, ATRX, and BRAFV600E mutation in astrocytic tumors and their significance in patient outcome in north Indian populationSemantic proximity Read ↗

Molecular alterations in the integrated diagnosis of pediatric glial and glioneuronal tumors: A single center experience.Semantic proximity Read ↗

Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene.Semantic proximity Read ↗

IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas.Semantic proximity Read ↗

IDH-1 polymorphisms in pilocytic astrocytomas.Semantic proximity Read ↗

The histomolecular criteria established for adult anaplastic pilocytic astrocytoma are not applicable to the pediatric populationSemantic proximity Read ↗

Pilocytic astrocytoma in adults: Histopathological, immunohistochemical and molecular study with clinical association.Semantic proximity Read ↗

The differential diagnosis of pilocytic astrocytoma with atypical features and malignant glioma: an analysis of 16 cases with emphasis on distinguishing molecular features.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.