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Article

Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells.

American journal of physiology. Lung cellular and molecular physiology - 1 Dec 2018

Tamò Luca, Hibaoui Youssef, Kallol Sampada, Alves Marco P, Albrecht Christiane, Hostettler Katrin E, Feki Anis, Rougier Jean-Sebastien, Abriel Hugues, Knudsen Lars, Gazdhar Amiq, Geiser Thomas

Abstract excerpt

Differentiation of primary alveolar type II epithelial cells (AEC II) to AEC type I in culture is a major barrier in the study of the alveolar epithelium in vitro. The establishment of an AEC II cell line derived from induced pluripotent stem cells (iPSC) represents a novel opportunity to study alveolar epithelial cell biology, for instance, in the context of lung injury, fibrosis, and repair. In the present...

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PMID: 30211653
DOI: 10.1152/ajplung.00357.2017

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