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Article

Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP.

Applied and environmental microbiology - 1 Apr 2012

Mo SangJoon, Yoo Young Ji, Ban Yeon Hee, Lee Sung-Kwon, Kim Eunji, Suh Joo-Won, Yoon Yeo Joon

Abstract excerpt

FK506 is an important 23-member polyketide macrolide with immunosuppressant activity. Its entire biosynthetic gene cluster was previously cloned from Streptomyces sp. strain KCTC 11604BP, and sequence analysis identified three putative regulatory genes, tcs2, tcs7, and fkbN, which encode proteins with high similarity to the AsnC family transcriptional regulators, LysR-type transcriptional regulators, and LAL...

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Identifiers

PMID: 22267670
DOI: 10.1128/AEM.06766-11
PMCID: PMC3302593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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