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FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

19 Oct 2012

Abstract excerpt

BACKGROUND: FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species. Considering the complex structure of FK506, it is reasonable to expect complex regulatory networks controlling its biosynthesis. Regulatory elements, present in gene clusters can have a profound influence on the final yield of target product and can play an important...

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PMID: 23083511
DOI: 10.1186/1471-2180-12-238

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