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Optimization of FK-506 production in Streptomyces tsukubaensis by modulation of Crp-mediated regulation

23 Mar 2023

Abstract excerpt

FK-506 is a potent immunosuppressive macrocyclic polyketide with growing pharmaceutical interest, produced by Streptomyces tsukubaensis. However, due to low levels synthesized by the wild-type strain, biotechnological production of FK-506 is rather limited. Optimization strategies to enhance the productivity of S. tsukubaensis by means of genetic engineering have been established. In this work primarily global...

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PMID: 36949330
DOI: 10.1007/s00253-023-12473-9

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