Donor HLA Class I Evolutionary Divergence and Late Allograft Rejection After Liver Transplantation in Children: An Emulated Target Trial.

doi:10.1111/tan.70320

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Article

Donor HLA Class I Evolutionary Divergence and Late Allograft Rejection After Liver Transplantation in Children: An Emulated Target Trial.

HLA - 1 Jul 2025

Dumortier Jérôme, Hamada Sarah, Wischlen Emma, Mandier Céline, Laverdure Noémie, Boillot Olivier, Kounis Ilias, Allain Vincent, Hervieu Valérie, Collardeau-Frachon Sophie, Dubois Valérie, Feray Cyrille

Abstract excerpt

HLA evolutionary divergence (HED), a continuous metric quantifying the differences between each amino acid of two homologous HLA alleles, reflects the importance of the immunopeptidome presented to T lymphocytes. It has been associated with rejection after liver transplantation. This retrospective cohort study aimed to analyse the potential effect of donor or recipient HED on liver transplant rejection in a new...

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Topics

Humans
Liver Transplantation
Graft Rejection
Child
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Child, Preschool

Adolescent

Retrospective Studies

Tissue Donors

Infant

Alleles

Histocompatibility Antigens Class I

Evolution, Molecular

Adult

Allografts

Histocompatibility Testing

Source

Open in PubMed

Identifiers

PMID: 40667760
DOI: 10.1111/tan.70320

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