Article
Conformational Flexibility in Respiratory Syncytial Virus G Neutralizing Epitopes.
Journal of virology - 28 Feb 2020
Fedechkin Stanislav O, George Natasha L, Nuñez Castrejon Ana M, Dillen Joshua R, Kauvar Lawrence M, DuBois Rebecca M
Abstract excerpt
Respiratory syncytial virus (RSV) is a top cause of severe lower respiratory tract disease and mortality in infants and the elderly. Currently, no vaccine or effective treatment exists for RSV. The RSV G glycoprotein mediates viral attachment to cells and contributes to pathogenesis by modulating host immunity through interactions with the human chemokine receptor CX3CR1. Antibodies targeting the RSV G central...
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