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Article

Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights.

Journal of biomolecular structure & dynamics - 1 Jan 2016

Chetty Sarentha, Bhakat Soumendranath, Martin Alberto J M, Soliman Mahmoud E S

Abstract excerpt

The PR20 HIV-1 protease, a variant with 20 mutations, exhibits high levels of multi-drug resistance; however, to date, there has been no report detailing the impact of these 20 mutations on the conformational and drug binding landscape at a molecular level. In this report, we demonstrate the first account of a comprehensive study designed to elaborate on the impact of these mutations on the dynamic features as...

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Source

Identifiers

PMID: 25671669
DOI: 10.1080/07391102.2015.1018326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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