Evaluating the potency of HIV-1 protease drugs to combat resistance.

Abstract excerpt

HIV-1 protease has been an important drug target for the antiretroviral treatment of HIV infection. The efficacy of protease drugs is impaired by the rapid emergence of resistant virus strains. Understanding the molecular basis and evaluating the potency of an inhibitor to combat resistance are no doubt important in AIDS therapy. In this study, we first identified residues that have significant contributions to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Darunavir
• Share to Drug Evaluation, Preclinical
• Share to Drug Resistance, Multiple, Viral