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Article

Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.

Journal of molecular biology - 1 Aug 2008

Liu Fengling, Kovalevsky Andrey Y, Tie Yunfeng, Ghosh Arun K, Harrison Robert W, Weber Irene T

Abstract excerpt

HIV-1 (human immunodeficiency virus type 1) protease (PR) and its mutants are important antiviral drug targets. The PR flap region is critical for binding substrates or inhibitors and catalytic activity. Hence, mutations of flap residues frequently contribute to reduced susceptibility to PR inhibitors in drug-resistant HIV. Structural and kinetic analyses were used to investigate the role of flap residues Gly48,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18597780
DOI: 10.1016/j.jmb.2008.05.062
PMCID: PMC2754059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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