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Article

Altered gut microbiome in FUT2 loss-of-function mutants in support of personalized medicine for inflammatory bowel diseases.

Journal of genetics and genomics = Yi chuan xue bao - 20 Sept 2021

Cheng Sijing, Hu Jun, Wu Xianrui, Pan Ji-An, Jiao Na, Li Yichen, Huang Yibo, Lin Xutao, Zou Yifeng, Chen Yuan, Zhu Lixin, Zhi Min, Lan Ping

Abstract excerpt

The FUT2 loss-of-function mutations are highly prevalent and are associated with inflammatory bowel disease (IBD). To investigate the impact of FUT2 loss-of-function mutation on the gut microbiota in patients with IBD, 81 endoscopically confirmed IBD patients were genotyped and divided into 3 groups: homozygous for functional FUT2 genes (SeSe), with one copy of non-functional FUT2 gene (Sese), or homozygous for...

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Identifiers

PMID: 34419617
DOI: 10.1016/j.jgg.2021.08.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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