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Article

Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype.

Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2011

Rausch Philipp, Rehman Ateequr, Künzel Sven, Häsler Robert, Ott Stephan J, Schreiber Stefan, Rosenstiel Philip, Franke Andre, Baines John F

Abstract excerpt

The FUT2 (Secretor) gene is responsible for the presence of ABO histo-blood group antigens on the gastrointestinal mucosa and in bodily secretions. Individuals lacking a functional copy of FUT2 are known as "nonsecretors" and display an array of differences in susceptibility to infection and disease, including Crohn disease. To determine whether variation in resident microbial communities with respect to FUT2...

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Identifiers

PMID: 22068912
DOI: 10.1073/pnas.1106408108
PMCID: PMC3223430

Genes

FUT2
ABO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype.PMID 22068912Read ↗

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Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiomeSemantic proximity Read ↗

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.Semantic proximity Read ↗

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