Article

Cluster mean-field theory accurately predicts statistical properties of large-scale DNA methylation patterns

2021-09-03

Abstract excerpt

The accurate establishment and maintenance of DNA methylation patterns is vital for mammalian development and disruption to these processes causes human disease. Our understanding of DNA methylation mechanisms has been facilitated by mathematical modelling, particularly stochastic simulations. Mega-base scale variation in DNA methylation patterns is observed in development, cancer and ageing and the mechanisms gen...

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Literature Corpus work: 2338194d-cc65-592b-be67-9df6714b5352
DOI: 10.1101/2021.09.03.458837

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