Article
Data-driven analysis of the kinetics of the JAK2V617F allele burden and blood cell counts during hydroxyurea treatment of patients with polycythemia vera, essential thrombocythemia, and primary myelofibrosis.
European journal of haematology - 1 Dec 2021
Dam Marc J B, Pedersen Rasmus K, Knudsen Trine A, Andersen Morten, Skov Vibe, Kjaer Lasse, Hasselbalch Hans C, Ottesen Johnny T
Abstract excerpt
BACKGROUND: Hydroxyurea (HU) treatment of patients with essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) (MPNs) normalizes elevated blood cell counts within weeks in the large majority of patients. Studies on the impact of HU upon the kinetics of the JAK2V617F allele burden, leukocyte, and platelet counts over time are scarce. PURPOSE: Using data-driven analysis as a novel...
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