Article
Data-driven analysis of JAK2V617F kinetics during interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms.
Cancer medicine - 1 Mar 2020
Pedersen Rasmus K, Andersen Morten, Knudsen Trine A, Sajid Zamra, Gudmand-Hoeyer Johanne, Dam Marc J B, Skov Vibe, Kjaer Lasse, Ellervik Christina, Larsen Thomas S, Hansen Dennis, Pallisgaard Niels, Hasselbalch Hans C, Ottesen Johnny T
Abstract excerpt
Treatment with PEGylated interferon-alpha2 (IFN) of patients with essential thrombocythemia and polycythemia vera induces major molecular remissions with a reduction in the JAK2V617F allele burden to undetectable levels in a subset of patients. A favorable response to IFN has been argued to depend upon the tumor burden, implying that institution of treatment with IFN should be as early as possible after the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.